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Can glutathione increase estrogen levels? 

Research Question

Can glutathione increase estrogen levels? 
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Academic Insights

The relationship between glutathione (GSH) and estrogen levels is complex, with some studies suggesting that estrogen may influence GSH levels rather than the other way around.

Key Insights

  • Estrogen and GSH Levels:
    • Research indicates that physiological serum estrogen during the menstrual cycle affects glutathione (GSH) and catalase activities. Higher estrogen levels are associated with higher GSH levels in erythrocytes .
    • Estrogen appears to modulate the activity of the ABCG2 transporter, which in turn affects intracellular GSH levels, suggesting a protective role of estrogen in maintaining GSH levels during ischemic injury .

Conclusion

While there is evidence that estrogen can influence glutathione levels, there is no direct evidence to suggest that glutathione increases estrogen levels. The relationship appears to be more about estrogen's role in modulating GSH levels and activity.

11

Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1

209 citations | Journal of Biological … | YM Qianet | 2001Cite
15

Glutathione metabolism during aging and in Alzheimer disease

325 citations | Annals of the New … | H Liuet | 2004Cite
19

Variability of glutathione during the menstrual cycle—due to estrogen effects on hepatocytes?

21 citations | Free Radical Biology and Medicine | C Dabrosinet | 2004Cite
20

Pyometra alters the redox status and expression of estrogen and progesterone receptors in the uterus of domestic cats

3 citations | Journal of Feline Medicine and Surgery | Acácia Eduarda de Jesus Nascimentoet | 2023Cite
24

The Energy Sensor AMPK: Adaptations to Exercise, Nutritional and Hormonal Signals

Spiegelman B. Hormones, Metabolism and the Benefits of Exercise, Hormones, Metabolism and the Benefits of Exercise, Springer, pp.13-24, 2018, Research and Perspectives in Endocrine Interactions, 978-3-319-72789-9 | Benoit Viollet | 2019Cite
26

Unbinding of Retinoic Acid from its Receptor Studied by Steered Molecular Dynamics

Biophysical Journal 76, 188 (1999) | Dorina Kosztinet | 1999Cite

Related Questions

  • What is the role of glutathione in hormone regulation?
  • How does glutathione affect estrogen metabolism?
  • Are there any studies linking glutathione and estrogen levels?
  • Can glutathione supplementation impact hormonal balance?
  • What are the health benefits of glutathione for women?

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