__________________ will inevitably make writing more difficult, and may block it altogether.

The statement suggests that something specific has a negative impact on writing, making it harder and possibly preventing it from happening entirely. While the blank can represent various factors such as "stress," "perfectionism," "lack of inspiration," or "distractions," it emphasizes the idea that certain conditions or feelings can heavily influence the writing process.

For instance, stress can hinder creativity and clarity of thought, leading to a block in writing. Similarly, perfectionism can cause a writer to become overly critical of their work, resulting in procrastination or an inability to finish writing projects. Distractions, whether from technology or environment, can also significantly disrupt focus and workflow.

In summary, the precise word or phrase that best fits the blank would depend on the context, but it clearly points to an obstacle that can impede the writing process.