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groups has the highest priority according to the Cahn-Ingold-Prelog sequence rules?

Question

Which groups have the highest priority according to the Cahn-Ingold-Prelog sequence rules?

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Solution

The Cahn-Ingold-Prelog (CIP) sequence rules are used to assign priority to different groups attached to a chiral center in a molecule. The priority is determined based on atomic number, with higher atomic numbers receiving higher priority.

Here are the steps to determine which group has the highest priority:

  1. Identify the atoms directly attached to the chiral center. The atom with the highest atomic number gets the highest priority.

  2. If there is a tie, move to the atoms one step away from the chiral center. Again, the group with the atom of highest atomic number gets the higher priority.

  3. If there is still a tie, continue moving away from the chiral center until the tie is broken.

  4. If all atoms are the same, then the group with the most branches gets the higher priority.

  5. If there is still a tie, then the group with the most double or triple bonds gets the higher priority.

So, without knowing the specific groups in your molecule, it's impossible to say which group has the highest priority. However, groups containing atoms with higher atomic numbers (like iodine or bromine) will generally have higher priority than groups containing atoms with lower atomic numbers (like hydrogen or carbon).

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