Which of the following was a significant challenge in building the Panama Canal?

The construction of the Panama Canal faced several significant challenges, including:

1. Geographical and Environmental Challenges: The dense jungle and mountainous terrain made construction difficult. The region's heavy rainfall led to frequent landslides and flooding.

2. Health Issues: Diseases such as malaria and yellow fever were rampant among workers, causing high mortality rates and significant delays.

3. Engineering Challenges: The canal required innovative engineering solutions, such as the construction of locks and the excavation of the Culebra Cut, which was a massive undertaking.

4. Financial and Political Challenges: Securing funding and political support was a constant struggle, especially after the initial French attempt failed.

Each of these challenges required significant effort and innovation to overcome, ultimately leading to the successful completion of the canal.