What is the net charge on the amino acid lysine at pH = 7.4 if pKa1 = 2.16, pKa2 = 9.06, and the pKa of the side chain = 10.54?A.+1B.+2C.0D.-1

Question

What is the net charge on the amino acid lysine at pH = 7.4 if pKa1 = 2.16, pKa2 = 9.06, and the pKa of the side chain = 10.54?A.+1B.+2C.0D.-1
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Solution 1

To determine the net charge of an amino acid at a given pH, we need to consider the pKa values of its ionizable groups and compare them to the pH.

Lysine has three ionizable groups: the amino group (pKa1 = 2.16), the carboxyl group (pKa2 = 9.06), and the side chain (pKa = 10.54).

At pH 7.4:

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