Huntington’s Disease is primarily caused by a specific type of DNA variation known as **Variable Number of Tandem Repeats (VNTR)**. The disease is linked to an expanded repeat of the CAG (cytosine-adenine-guanine) triplet in the HTT gene, located on chromosome 4. In healthy individuals, this repeat typically ranges from 10 to 35 times, while in individuals with Huntington's Disease, the repeat can increase to 36 or more.

This abnormal expansion results in the production of an altered version of the huntingtin protein, which ultimately leads to neuronal degeneration and the characteristic symptoms of the disease. Therefore, the correct answer to the question about the type of DNA variation that causes Huntington’s Disease is:

**Variable Number of Tandem Repeat (VNTR)**.

Question

Huntington’s Disease is primarily caused by a specific type of DNA variation known as **Variable Number of Tandem Repeats (VNTR)**. The disease is linked to an expanded repeat of the CAG (cytosine-adenine-guanine) triplet in the HTT gene, located on chromosome 4. In healthy individuals, this repeat typically ranges from 10 to 35 times, while in individuals with Huntington's Disease, the repeat can increase to 36 or more.

This abnormal expansion results in the production of an altered version of the huntingtin protein, which ultimately leads to neuronal degeneration and the characteristic symptoms of the disease. Therefore, the correct answer to the question about the type of DNA variation that causes Huntington’s Disease is:

**Variable Number of Tandem Repeat (VNTR)**.

Knowee AI · Accepted Answer

Huntington’s Disease is primarily caused by a specific type of DNA variation known as **Variable Number of Tandem Repeats (VNTR)**. The disease is linked to an expanded repeat of the CAG (cytosine-adenine-guanine) triplet in the HTT gene, located on chromosome 4. In healthy individuals, this repeat typically ranges from 10 to 35 times, while in individuals with Huntington's Disease, the repeat can increase to 36 or more.

This abnormal expansion results in the production of an altered version of the huntingtin protein, which ultimately leads to neuronal degeneration and the characteristic symptoms of the disease. Therefore, the correct answer to the question about the type of DNA variation that causes Huntington’s Disease is:

**Variable Number of Tandem Repeat (VNTR)**.

Huntington’s Disease is caused by which type of DNA variation?Copy Number Variant (CNV)DeletionVariable Number of Tandem Repeat (VNTR)Duplication

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Huntington’s Disease is caused by which type of DNA variation?

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