Hemochromatosis overrides what protection the body usually has from iron toxicity?Multiple choice question.ChelationMicrovilliMucosal block

Question Analysis

In hemochromatosis, the body absorbs too much iron from the diet, leading to iron overload and potential toxicity. To answer the question properly, we need to analyze the protective mechanisms that are typically in place against iron toxicity.

Relevant Concepts

1. Chelation: This refers to the process by which chelating agents bind to metal ions, including iron, making them excretable and less toxic.
2. Microvilli: These are microscopic cellular membrane protrusions that increase surface area and are involved in nutrient absorption in the intestine.
3. Mucosal block: This refers to the mechanism by which the intestinal mucosa regulates and restricts the absorption of certain substances, including iron, under normal circumstances.

Analysis of Options

1. Chelation: While chelation is a treatment for iron overload, it is not a primary protective mechanism against iron toxicity within the body.
2. Microvilli: They primarily serve to absorb nutrients rather than protect against iron overload.
3. Mucosal block: This is the protective mechanism that restricts excessive iron absorption in a healthy system, but this mechanism is overridden in cases of hemochromatosis, leading to increased iron levels.

Conclusion

The correct answer is Mucosal block, as hemochromatosis overrides the body's natural mucosal block mechanism that would typically prevent iron overload.

Final Answer

Hemochromatosis overrides Mucosal block.