Sacubitril valsartan is no more effective than an ACE inhibitor in heart failure with reduced ejection fraction.Question 5Answera.Falseb.True
Question
Sacubitril valsartan is no more effective than an ACE inhibitor in heart failure with reduced ejection fraction.
Question 5
Answer
- a. False
- b. True
Solution
Analyzing the Statement
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Understanding the Context: Sacubitril valsartan (Entresto) is a combination medication used to treat heart failure with reduced ejection fraction (HFrEF). It combines a neprilysin inhibitor (sacubitril) with an angiotensin receptor blocker (valsartan).
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Research Background: Clinical trials, particularly the PARADIGM-HF trial, compared sacubitril valsartan to an ACE inhibitor (enalapril). The results indicated that sacubitril valsartan significantly reduced cardiovascular death and hospitalization for heart failure compared to enalapril.
Conclusion
Based on the available evidence from clinical studies, the statement "Sacubitril valsartan is no more effective than an ACE inhibitor in heart failure with reduced ejection fraction" is False.
Therefore, the correct answer is a. False.
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