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This neurotransmitter system utilizes an extracellular enzyme for signal termination

Question

This neurotransmitter system utilizes an extracellular enzyme for signal termination

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Solution

The neurotransmitter system that utilizes an extracellular enzyme for signal termination is the Acetylcholine (ACh) system. Here's the step-by-step process:

  1. Transmission begins when an action potential triggers the release of ACh from the presynaptic neuron into the synaptic cleft.

  2. The ACh molecules then bind to ACh receptors on the postsynaptic neuron, initiating a response in that neuron.

  3. To terminate the signal, an enzyme called acetylcholinesterase (AChE) breaks down the ACh in the synaptic cleft. This enzyme is located in the extracellular space (outside the cells), hence it is referred to as an extracellular enzyme.

  4. The breakdown products of ACh (acetate and choline) are then taken up by the presynaptic neuron and used to synthesize new ACh molecules, which can be released when the next action potential arrives.

  5. This process ensures that the neurotransmitter signal is quickly terminated after it has been transmitted, preventing continuous activation of the postsynaptic neuron and allowing for precise control of neurotransmission.

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