During vertebrate development, the bones in appendages are first modeled in , which is later replaced with living bone.

During vertebrate development, the bones in appendages are first modeled in cartilage, which is later replaced with living bone. This process is known as endochondral ossification.

Here are the steps:

1. Mesenchymal cells, a type of stem cell, gather together at the site where the bone will form. Knowee AI is a powerful AI-powered study tool designed to help you to solve study problem.