The U.S. free trade agreement with Costa Rica, the Dominican Republic, El Salvador, Guatemala, Nicaragua, and Honduras is .

The U.S. free trade agreement with Costa Rica, the Dominican Republic, El Salvador, Guatemala, Nicaragua, and Honduras is known as the Dominican Republic-Central America Free Trade Agreement (CAFTA-DR).

Here are the steps to answer this question:

1. Identify the countries mentioned in the question: Costa Rica, the Dominican Republic, El Salvador, Guatemala, Nicaragua, and Honduras.
2. Recognize that these countries are part of Central America and the Caribbean.
3. Recall or research major U.S. free trade agreements with these regions.
4. Identify the Dominican Republic-Central America Free Trade Agreement (CAFTA-DR) as the agreement that includes all of these countries.
5. Confirm that the CAFTA-DR is a free trade agreement between the U.S. and the countries listed in the question.
6. Formulate the answer: The U.S. free trade agreement with Costa Rica, the Dominican Republic, El Salvador, Guatemala, Nicaragua, and Honduras is known as the Dominican Republic-Central America Free Trade Agreement (CAFTA-DR).