What gastrokinetic agent has a blackbox warning of cardiac arrhythmia and Long QT syndrome?*1 pointMetoclopramidePinaverium bromideIsaperoneFluoxetineCisapride

Answer

The gastrokinetic agent that has a black box warning for cardiac arrhythmia and Long QT syndrome is Cisapride.

Cisapride is a medication that was used to treat gastroesophageal reflux disease (GERD) and other gastrointestinal motility disorders. However, it was associated with serious cardiovascular side effects, particularly the potential for causing arrhythmias and prolonging the QT interval on an electrocardiogram. This led to a significant concern for patient safety, and as a result, the FDA issued a black box warning highlighting these risks.

Due to these safety concerns, Cisapride has been withdrawn from the market in many countries, although it remains available in some areas under strict regulation. Other medications listed, such as Metoclopramide and Fluoxetine, also carry their own risks but do not share the same warnings specifically related to cardiac arrhythmias and Long QT syndrome as Cisapride.