The gland is closely associated with the area of the brain called the hypothalamus.

The gland closely associated with the hypothalamus is the pituitary gland.

Detailed Explanation:

1. Location and Structure: The pituitary gland is a pea-sized structure located at the base of the brain, just below the hypothalamus. It is often referred to as the "master gland" of the endocrine system because it regulates the functions of other endocrine glands.

2. Function: The hypothalamus and pituitary gland work together to control various bodily functions, including growth, metabolism, and reproduction. The hypothalamus produces releasing and inhibiting hormones that directly influence the pituitary gland's secretion of hormones.

3. Hormonal Regulation: The pituitary gland releases several key hormones such as growth hormone (GH), thyroid-stimulating hormone (TSH), and adrenocorticotropic hormone (ACTH), which regulate various physiological processes throughout the body.

4. Feedback Mechanisms: The relationship between the hypothalamus and pituitary gland exemplifies the principle of feedback mechanisms, where the levels of hormones in the bloodstream influence the release of hormones by both glands.

Overall, the intricate connection between the hypothalamus and the pituitary gland plays a critical role in maintaining homeostasis and regulating the body's hormonal balance.