The matrix of connective tissue consists of substance (which often contains fluid) and fibers made of .

The matrix of connective tissue consists of ground substance (which often contains fluid) and fibers made of proteins. The ground substance is a gel-like material that fills the space between the cells and contains the fibers. It provides a medium through which nutrients and other substances can be exchanged between the blood and the cells.

The fibers provide support and structure to the tissue. There are three types of fibers found in the matrix of connective tissue:

1. Collagen fibers: These are the most common type of fiber in connective tissue. They are strong and flexible, and they provide resistance to stretching.

2. Elastic fibers: These fibers are smaller in diameter than collagen fibers, and they are more flexible. They allow the tissue to return to its original shape after it has been stretched or compressed.

3. Reticular fibers: These are the smallest and shortest fibers, and they form a network that supports the cells and ground substance.

In summary, the matrix of connective tissue is made up of ground substance and fibers (collagen, elastic, and reticular), which are made of proteins.