In cartilage, the ground substance contains a glycoprotein called , and the matrix contains fibers arranged in parallel.

In cartilage, the ground substance contains a glycoprotein called aggrecan, which is essential for the tissue's ability to withstand compressive forces. Aggrecan is a large aggregating proteoglycan that plays a critical role in cartilage's hydration and resilience.

Additionally, the matrix of cartilage contains collagen fibers that are arranged in parallel. Specifically, type II collagen is predominant in hyaline cartilage, providing tensile strength and structural integrity, while its parallel arrangement allows for flexibility and support under stress.

This combination of aggrecan in the ground substance and collagen fibers in the matrix gives cartilage its unique properties, such as cushioning and resistance to compression, making it vital for joint function and overall musculoskeletal health.