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_catalyses the formation of phosphodiester bond between two deoxynucleotide residues of two DNA strands

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Solution

The enzyme that catalyzes the formation of a phosphodiester bond between two deoxynucleotide residues of two DNA strands is DNA polymerase.

Here are the steps of how this process occurs:

  1. Initiation: The process begins with the unwinding of the double-stranded DNA by an enzyme called helicase. This creates a replication fork where DNA polymerase can begin its work.

  2. Primer Binding: A short RNA primer is synthesized by an enzyme called primase. This primer serves as a starting point for DNA polymerase.

  3. Elongation: DNA polymerase adds free nucleotides to the 3' end of the primer, forming a new strand of DNA. It does this by catalyzing the formation of a phosphodiester bond between the phosphate group of the incoming nucleotide and the 3' OH of the last nucleotide in the growing strand.

  4. Termination: Once the entire DNA molecule has been replicated, the process is terminated. The RNA primers are removed and replaced with DNA by another DNA polymerase, and the fragments of DNA are joined together by an enzyme called DNA ligase.

So, in summary, the enzyme that catalyzes the formation of a phosphodiester bond between two deoxynucleotide residues of two DNA strands is DNA polymerase.

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