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Briefly explain the process of glycogenolysis (2 marks) and what hormone stimulates this process

Question

Briefly explain the process of glycogenolysis (2 marks) and what hormone stimulates this process

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Solution

Glycogenolysis is the process by which glycogen, a multi-branched polysaccharide of glucose, is broken down into a glucose molecule in the liver and muscle.

Step 1: The first step in glycogenolysis is the release of glucose-1-phosphate from glycogen by the enzyme glycogen phosphorylase.

Step 2: The glucose-1-phosphate is then converted to glucose-6-phosphate by the enzyme phosphoglucomutase.

Step 3: In the liver cells, glucose-6-phosphatase converts glucose-6-phosphate into free glucose. This glucose can then be released into the bloodstream for use by other cells as an energy source.

The hormone that stimulates this process is glucagon. When blood glucose levels are low, glucagon is released from the alpha cells of the pancreas. This hormone triggers the process of glycogenolysis to increase blood glucose levels.

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