A cellular organelle commonly affected in Neurodegenerative diseases is the nucleus1mitochondria2cell membrane3axon4

In neurodegenerative diseases, the organelle that is most commonly affected is mitochondria. Mitochondria are crucial for energy production in cells and are involved in various processes, including apoptosis and regulation of cellular metabolism. Dysfunction of mitochondria is linked to several conditions, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. This impairment contributes to neuronal cell death and the progression of neurodegenerative disorders. Research indicates that mitochondrial dysfunction induces oxidative stress, disrupts calcium homeostasis, and leads to impaired energy metabolism, all of which are critical factors in the pathophysiology of these diseases.