What is the effect of L-Lysine on viruses?
Research Question
Academic Insights
L-Lysine has shown potential in both inhibiting and promoting viral replication, depending on the virus and context, highlighting its complex role in antiviral therapy.
Key Insights
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Inhibition of Viral Replication:
- L-Lysine can interfere with the formation of capsid proteins and DNA by competing with arginine, an essential amino acid for some viruses, thereby potentially controlling viral infections .
- ε-Poly-L-lysine (ε-PL), a homopolymer of L-lysine, has been shown to fragment tobacco mosaic virus (TMV) virions and delay systemic infection, indicating its antiviral properties .
- Antisense oligomers linked to poly(L-lysine) (PLL) exhibit enhanced antiviral properties against vesicular stomatitis virus (VSV) and HIV-1 by increasing the uptake and effectiveness of the oligomers .
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Promotion of Viral Replication:
- In HIV-1 infected patients, L-Lysine supplementation significantly increased HIV-1 RNA replication, suggesting that high intake of L-Lysine may accelerate viral load and disease progression .
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Therapeutic Applications:
- Combination treatments involving L-Lysine and antiviral drugs have shown clinical effectiveness in treating feline herpesvirus-1 (FHV-1) infections in cats, with significant improvement in symptoms and reduction in viral DNA .
Conclusion
L-Lysine exhibits a dual role in viral replication, acting as both an inhibitor and promoter depending on the virus and context. While it shows promise in controlling certain viral infections, its potential to increase viral load in others, such as HIV-1, necessitates careful consideration and further research to optimize its use in antiviral therapies.
L‐lysine: Its antagonism with L‐arginine in controlling viral infection. Narrative literature review
Influence of L-lysine amino acid on the HIV-1 RNA replication in vitro
Biological activity of oligonucleotide-poly(L-lysine) conjugates: mechanism of cell uptake.
Antiviral Activity of a Turbot (Scophthalmus maximus) NK-Lysin Peptide by Inhibition of Low-pH Virus-Induced Membrane Fusion
Transcriptomic and Functional Analyses Indicate Novel Anti-viral Mode of Actions on Tobacco Mosaic Virus of a Microbial Natural Product ε-Poly-l-lysine.
Clinical evaluation of antiviral combination treatment in cats with feline herpesvirus-1 infection.
Fungal Enzyme l-Lysine α-Oxidase Affects the Amino Acid Metabolism in the Brain and Decreases the Polyamine Level
Poly(L-lysine)-conjugated oligonucleotides promote sequence-specific inhibition of acute HIV-1 infection.
Failure To Cleave Murine Leukemia Virus Envelope Protein Does Not Preclude Its Incorporation in Virions and Productive Virus-Receptor Interaction
Vaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues
[Effect of L-lysine alpha-oxidase from Trichoderma cf. aureoviride Rifai ВКМF-4268D on pheochromocytoma PC12 cell line].
The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate
Inhibition of DNA ejection from bacteriophage by Mg+2 counterions
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Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PLpro Protein
In Silico Investigation of Phytoconstituents from Indian Medicinal Herb 'Tinospora cordifolia (Giloy)' against SARS-CoV-2 (COVID-19) by Molecular Dynamics Approach
Copper and silver thin film systems display differences in antiviral and antibacterial properties -- implications for the prevention of SARS-CoV-2 infections
The efficacy of antiviral drug, HIV viral load and the immune response
Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus
Molecular docking and binding mode analysis of selected FDA approved drugs against COVID-19 selected key protein targets: An effort towards drug repurposing to identify the combination therapy to combat COVID-19
Effects of surface charge and environmental factors on the electrostatic interaction of fiber with virus-like particle: A case of coronavirus
The Red clover necrotic mosaic virus capsid protein N-terminal lysine-rich motif is a determinant of symptomatology and virion accumulation.
A Touch of Sleep: Biophysical Model of Contact-mediated Dormancy of Archaea by Viruses
Time Optimal Control Studies on COVID-19 Incorporating Adverse Events of the Antiviral Drugs
Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection
Patch formation driven by stochastic effects of interaction between viruses and defective interfering particles
Related Questions
- How does L-Lysine interact with the immune system?
- What viruses are most affected by L-Lysine?
- Are there any side effects of L-Lysine when taken for viral infections?
- What is the recommended dosage of L-Lysine for antiviral effects?
- Can L-Lysine be used alongside other antiviral treatments?
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