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What are the effects of using 200mg of testosterone per week? 

Research Question

What are the effects of using 200mg of testosterone per week? 
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Academic Insights

The effects of using 200mg of testosterone per week include a delayed but broad stimulatory effect on muscle protein synthesis during energy deficit, resulting in muscle mass accretion during recovery, but also potential toxic effects on the liver and cardiac muscle when used in supraphysiological doses.

Key Insights

  • Muscle Protein Synthesis and Mass:
    • Testosterone at 200mg per week can stimulate muscle protein synthesis rates across the muscle proteome during energy deficit, leading to increased muscle mass during recovery periods .
  • Liver and Cardiac Muscle Effects:
    • Chronic use of testosterone enanthate in high doses can cause significant histopathological and biochemical changes in the liver and cardiac muscle, including hypertrophy, fibrosis, and cellular damage, which may lead to loss of function .

Conclusion

Using 200mg of testosterone per week can enhance muscle protein synthesis and mass during recovery from energy deficits, but caution is advised due to potential toxic effects on the liver and cardiac muscle when used in higher doses.

1

Effects of testosterone on mixed-muscle protein synthesis and proteome dynamics during energy deficit.

5 citations | The Journal of clinical endocrinology and metabolism | Emily E. Howardet | 2022Cite
2

HEPATOTOXIC AND CARDIOTOXIC EFFECTS OF TESTOSTERONE ENANTHATE ABUSE ON ADULT MALE ALBINO RATS

3 citations | al-azhar medical journal | M. E. El-Gendyet | 2021Cite
5

Testosterone Therapy Effects on Bone Mass and Turnover in Hypogonadal Men with Type 2 Diabetes.

14 citations | The Journal of clinical endocrinology and metabolism | G. Colleluoriet | 2021Cite
9

Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies

The Journal of steroid biochemistry and molecular biology (2021) 210: 105878 | Joseph Whittakeret | 2022Cite
21

Profiling of FSHR Negative Allosteric Modulators on LH/CGR Reveals Biased Antagonism with Implications in Steroidogenesis

Molecular and Cellular Endocrinology, 436:10--22 (2016) | Mohammed Akli Ayoubet | 2018Cite

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