The major barrier to transdermal drug transport is percutaneous absorption. True False

The statement is True.

Percutaneous absorption refers to the process by which drugs penetrate the skin and enter the systemic circulation. The skin acts as a significant barrier to the absorption of many substances, including drugs. This barrier function is due to the structure of the skin, particularly the stratum corneum, which is composed of tightly packed dead skin cells and lipids. This structure limits the permeability of drugs and makes transdermal delivery challenging.

In summary, the major barrier to transdermal drug transport indeed lies in the percutaneous absorption process, as it must overcome the skin's protective properties to effectively deliver therapeutic agents into the body.