Comment on the application of enzymes in the treatment of diseases. Provide examples (minimum 4) of drugs enzyme.

Enzymes play a crucial role in the treatment of various diseases. They are biological catalysts that speed up chemical reactions in the body. Enzymes can be used directly as therapeutic agents, or they can be used to activate or deactivate drugs.

1. L-asparaginase: This enzyme is used in the treatment of acute lymphoblastic leukemia. It works by breaking down asparagine, an amino acid that is essential for the growth of cancer cells, thereby inhibiting their proliferation.

2. Alglucerase: This enzyme is used in the treatment of Gaucher's disease, a genetic disorder in which a type of fat (lipid) accumulates in cells and certain organs. Alglucerase works by breaking down this lipid.

3. Streptokinase: This enzyme is used to dissolve blood clots in patients with certain heart or blood vessel conditions. It works by activating the body's own system for breaking down blood clots.

4. Pancrelipase: This is a combination of several enzymes (protease, lipase, and amylase) that are normally produced by the pancreas. It is used in conditions where the pancreas cannot make or does not release enough digestive enzymes into the gut to digest the food.

These are just a few examples of how enzymes are used in the treatment of diseases. The field of enzyme therapy is continually evolving, with ongoing research into new applications and improved delivery methods.