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Which allele combination represents a male who has an X-linked recessive disorder?

Question

Which allele combination represents a male who has an X-linked recessive disorder?

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Solution

Step 1: Define the Problem

Identify the genetic makeup of a male with an X-linked recessive disorder.

Step 2: Break Down the Problem

  1. Understand the nature of X-linked recessive disorders.
  2. Determine how these disorders are inherited in males.

Step 3: Apply Relevant Concepts

  • X-linked Recessive Disorders: These are conditions caused by mutations in genes on the X chromosome. Since males have one X and one Y chromosome (XY), they will express the disorder if they inherit the affected X chromosome because they do not have a second X chromosome to mask the effect.
  • Inheritance in Males: A male inherits his X chromosome from his mother and his Y chromosome from his father.

Step 4: Analysis, Verify and Summarize

  • A male with an X-linked recessive disorder has the genotype X^rY, where X^r represents the X chromosome carrying the recessive allele for the disorder.
  • Since males have only one X chromosome, the presence of the recessive allele on this chromosome will result in the expression of the disorder.

Final Answer

The allele combination for a male with an X-linked recessive disorder is XrY X^rY .

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