The nine-base AT-rich sequence of the Recombination Signal Sequences (RSS) during heavy chain rearrangement functions to signal the recombination machinery where to bind and cut the DNA. This is a crucial step in the process of V(D)J recombination, which is responsible for the diversity of the immune system.

Here are the steps:

1. The recombination machinery, which includes the proteins RAG1 and RAG2, recognizes and binds to the RSS.

2. The DNA is cut at the border of the RSS and the coding sequence.

3. The coding sequences are then joined together in a process called ligation, resulting in a rearranged gene that can produce a unique protein.

4. The intervening sequences are looped out and deleted.

5. The rearranged gene is then transcribed and translated into a unique heavy chain protein, contributing to the diversity of antibodies that the immune system can produce.

Question

The nine-base AT-rich sequence of the Recombination Signal Sequences (RSS) during heavy chain rearrangement functions to signal the recombination machinery where to bind and cut the DNA. This is a crucial step in the process of V(D)J recombination, which is responsible for the diversity of the immune system.

Here are the steps:

1. The recombination machinery, which includes the proteins RAG1 and RAG2, recognizes and binds to the RSS.

2. The DNA is cut at the border of the RSS and the coding sequence.

3. The coding sequences are then joined together in a process called ligation, resulting in a rearranged gene that can produce a unique protein.

4. The intervening sequences are looped out and deleted.

5. The rearranged gene is then transcribed and translated into a unique heavy chain protein, contributing to the diversity of antibodies that the immune system can produce.

Knowee AI · Accepted Answer

The nine-base AT-rich sequence of the Recombination Signal Sequences (RSS) during heavy chain rearrangement functions to signal the recombination machinery where to bind and cut the DNA. This is a crucial step in the process of V(D)J recombination, which is responsible for the diversity of the immune system.

Here are the steps:

1. The recombination machinery, which includes the proteins RAG1 and RAG2, recognizes and binds to the RSS.

2. The DNA is cut at the border of the RSS and the coding sequence.

3. The coding sequences are then joined together in a process called ligation, resulting in a rearranged gene that can produce a unique protein.

4. The intervening sequences are looped out and deleted.

5. The rearranged gene is then transcribed and translated into a unique heavy chain protein, contributing to the diversity of antibodies that the immune system can produce.

Duringheavy chain rearrangement, the nine-base AT-rich sequence of the RSS functionsto ______.

Question

During heavy chain rearrangement, the nine-base AT-rich sequence of the RSS functions to ______.

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