ow many different MHC class I molecules will normally be expressed on the surface of a human cell?
Question
How many different MHC class I molecules will normally be expressed on the surface of a human cell?
Solution
The number of different Major Histocompatibility Complex (MHC) class I molecules that will normally be expressed on the surface of a human cell can vary, but typically, each human cell expresses several types of MHC class I molecules.
- Each individual has two alleles of each MHC class I gene, one inherited from each parent.
- The most common MHC class I genes in humans are HLA-A, HLA-B, and HLA-C.
- Therefore, a normal human cell may express multiple combinations of these MHC molecules based on genetic diversity and individual allele variations.
In general, most human cells will express at least 6 to 12 different MHC class I molecules at any one time, depending on the genetic makeup of the individual. In summary, a typical human cell expresses various MHC class I molecules, primarily from the HLA-A, HLA-B, and HLA-C gene families.
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