Which of the given chemicals is used as ‘clot buster’ in patients who have undergone myocardial infarction leading to heart attack?
Question
Which of the given chemicals is used as ‘clot buster’ in patients who have undergone myocardial infarction leading to heart attack?
Solution
The chemical commonly referred to as a 'clot buster' used in patients who have experienced a myocardial infarction (heart attack) is thrombolytic agents. The most widely used thrombolytic medications include:
- Alteplase (tPA): A tissue plasminogen activator that helps dissolve blood clots.
- Reteplase: Another form of tPA with a different molecular structure that also helps in breaking down clots.
- Tenecteplase: A genetically modified form of tPA that has a longer half-life, allowing for quicker administration.
These medications work by converting plasminogen to plasmin, which then breaks down fibrin in the blood clot, allowing for reinstatement of blood flow to the heart muscle and minimizing damage. The timely administration of these drugs is critical in improving the outcomes for patients post-myocardial infarction.
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