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Gastric Secretions? secretions of oxynticglands and pyloric glands? Relationship withPernicious anemia?

Question

Gastric Secretions?

secretions of oxyntic glands and pyloric glands?

Relationship with Pernicious anemia?

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Solution

Gastric secretions are the substances produced and released by cells in the stomach to facilitate digestion. These secretions include hydrochloric acid, pepsinogen, intrinsic factor, mucus, and bicarbonate.

  1. Oxyntic glands: These are found in the body and fundus of the stomach. They secrete hydrochloric acid and intrinsic factor. Hydrochloric acid helps to break down food and activate enzymes, while intrinsic factor is necessary for the absorption of vitamin B12 in the small intestine.

  2. Pyloric glands: These are located in the antrum of the stomach. They secrete gastrin, a hormone that stimulates the secretion of gastric acid by the parietal cells of the stomach.

Pernicious anemia is a condition that occurs when the body is unable to absorb enough vitamin B12 from the diet due to a lack of intrinsic factor. This can be caused by an autoimmune reaction where the body's immune system attacks the cells in the stomach that produce intrinsic factor.

The relationship between gastric secretions and pernicious anemia is therefore centered on the role of intrinsic factor. Without sufficient intrinsic factor, vitamin B12 cannot be absorbed properly, leading to a deficiency and the development of pernicious anemia.

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