S. aureus produces a virulence factor called protein A.Protein A binds to the Fc portion of antibodies. This can be beneficial for the bacteria because:
Question
S. aureus produces a virulence factor called protein A.
Protein A binds to the Fc portion of antibodies. This can be beneficial for the bacteria because:
Solution
Staphylococcus aureus, commonly known as S. aureus, produces a virulence factor called Protein A. This protein has a unique ability to bind to the Fc portion of antibodies, which are proteins produced by the body's immune system to fight off infections.
Here's how this can be beneficial for the bacteria:
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Immune Evasion: By binding to the Fc portion of antibodies, Protein A prevents these antibodies from being recognized by immune cells. Normally, the Fc region of an antibody binds to Fc receptors on immune cells, signaling them to destroy the pathogen. When Protein A binds to the Fc region, it blocks this interaction, effectively hiding the bacteria from the immune system.
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Prevention of Opsonization: Opsonization is a process where pathogens are marked for destruction by the immune system. Antibodies play a key role in this process by binding to pathogens and signaling immune cells to destroy them. However, when Protein A binds to the Fc region of an antibody, it prevents the antibody from marking the bacteria for destruction, allowing the bacteria to survive and multiply.
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Inhibition of Complement Activation: The complement system is a part of the immune system that enhances the ability of antibodies to clear microbes and damaged cells from an organism. It promotes inflammation and attacks the pathogen's cell membrane. By binding to the Fc portion of antibodies, Protein A can inhibit the activation of the complement system, further helping the bacteria evade the immune response.
In summary, the production of Protein A by S. aureus provides the bacteria with a mechanism to evade the host's immune response, thereby increasing its chances of survival and proliferation.
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