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Which of the following is a web server for discriminating and predicting the protein stability upon mutation? FOLD-RATE iSEE ProTherm CUPSAT

Question

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Solution

The question asks about a web server specifically designed for predicting protein stability upon mutation. Here’s a breakdown of each option:

  1. FOLD-RATE: This server focuses on the prediction of the folding rates of proteins but may not be specifically tailored for assessing stability upon mutation.

  2. iSEE: This is typically a web tool used for various bioinformatics analyses but does not solely specialize in predicting protein stability due to mutations.

  3. ProTherm: This database contains information on protein stability and thermal denaturation. It can provide insights into the stability of proteins but is more of a database than a predictive tool.

  4. CUPSAT: This tool is explicitly designed for assessing the stability of proteins upon mutation. It uses statistical mechanics principles to predict how mutations affect protein stability.

Final Answer

CUPSAT is the web server specifically designed for discriminating and predicting protein stability upon mutation.

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