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Which enzyme is primarily responsible for initiating glycogenolysis?Question 13Answera.Glycogen synthaseb.Glycogen phosphorylasec.Hexokinased.Glucokinase

Question

Which enzyme is primarily responsible for initiating glycogenolysis?

Question 13
Answer

  • a. Glycogen synthase
  • b. Glycogen phosphorylase
  • c. Hexokinase
  • d. Glucokinase
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Solution

The enzyme primarily responsible for initiating glycogenolysis is b. Glycogen phosphorylase.

Here's a step-by-step explanation:

  1. Glycogenolysis is the process of breaking down glycogen, a multi-branched polysaccharide of glucose, into glucose-1-phosphate and glucose.

  2. This process is regulated by two enzymes: glycogen phosphorylase and glycogen synthase.

  3. Glycogen phosphorylase is the enzyme that initiates glycogenolysis. It breaks the alpha-1,4 glycosidic linkages between the glucose molecules in the glycogen chain, releasing glucose-1-phosphate.

  4. On the other hand, glycogen synthase is the enzyme that is responsible for the synthesis of glycogen. It is not involved in glycogenolysis, but rather in the opposite process, glycogenesis.

  5. Hexokinase and glucokinase are enzymes involved in the phosphorylation of glucose to glucose-6-phosphate, a step in both glycogen synthesis and glycolysis, but they do not initiate glycogenolysis.

This problem has been solved

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