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Which of the following peptides would exhibit the greatest steric constraints?A.AGSCTNB.ICGHLAC.PDNETQD.FYLWIR

Question

Which of the following peptides would exhibit the greatest steric constraints?

  • A. AGSCTN
  • B. ICGHLAC
  • C. PDNETQD
  • D. FYLWIR
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Solution

The peptide that would exhibit the greatest steric constraints would be the one with the largest and most complex side chains, as these would create the most hindrance in terms of spatial arrangement.

Looking at the given peptides:

A. AGSCTN - This peptide contains relatively small side chains, with Cysteine (C) being the largest.

B. ICGHLA - This peptide contains Isoleucine (I) and Leucine (L), which are larger and more complex than any in peptide A.

C. PDNETQ - This peptide contains Aspartic acid (D), Glutamic acid (E), and Glutamine (Q), which are larger and more complex than any in peptide A, but not necessarily larger than Isoleucine (I) and Leucine (L) in peptide B.

D. FYLWIR - This peptide contains Phenylalanine (F), Tyrosine (Y), Tryptophan (W), and Arginine (R), which are among the largest and most complex of the amino acids.

Therefore, peptide D (FYLWIR) would likely exhibit the greatest steric constraints due to the size and complexity of its side chains.

This problem has been solved

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