Phosphofructokinase 1 (PFK1) is a key enzyme in the glycolytic pathway. It is regulated by several metabolites, with ATP and citrate being known inhibitors and ADP being a known activator.

Here are the steps to answer your question:

1. ATP: ATP is an inhibitor of PFK1. When ATP levels are high, it binds to PFK1 and decreases its activity. This makes sense because high ATP levels signal that the cell has enough energy, so it doesn't need to break down more glucose through glycolysis.

2. ADP: ADP is an activator of PFK1. When ADP levels are high, it binds to PFK1 and increases its activity. This is because high ADP levels signal that the cell needs more energy, so it needs to break down more glucose through glycolysis.

3. Citrate: Citrate is an inhibitor of PFK1. When citrate levels are high, it binds to PFK1 and decreases its activity. This is because high citrate levels signal that the cell has enough building blocks for the citric acid cycle, so it doesn't need to break down more glucose through glycolysis.

4. Acetyl CoA: Acetyl CoA does not directly regulate PFK1. However, it is a product of glycolysis and can be used in the citric acid cycle to produce ATP.

So, the answer to your question is "ADP".

Question

Phosphofructokinase 1 (PFK1) is a key enzyme in the glycolytic pathway. It is regulated by several metabolites, with ATP and citrate being known inhibitors and ADP being a known activator.

Here are the steps to answer your question:

1. ATP: ATP is an inhibitor of PFK1. When ATP levels are high, it binds to PFK1 and decreases its activity. This makes sense because high ATP levels signal that the cell has enough energy, so it doesn't need to break down more glucose through glycolysis.

2. ADP: ADP is an activator of PFK1. When ADP levels are high, it binds to PFK1 and increases its activity. This is because high ADP levels signal that the cell needs more energy, so it needs to break down more glucose through glycolysis.

3. Citrate: Citrate is an inhibitor of PFK1. When citrate levels are high, it binds to PFK1 and decreases its activity. This is because high citrate levels signal that the cell has enough building blocks for the citric acid cycle, so it doesn't need to break down more glucose through glycolysis.

4. Acetyl CoA: Acetyl CoA does not directly regulate PFK1. However, it is a product of glycolysis and can be used in the citric acid cycle to produce ATP.

So, the answer to your question is "ADP".

Knowee AI · Accepted Answer

Phosphofructokinase 1 (PFK1) is a key enzyme in the glycolytic pathway. It is regulated by several metabolites, with ATP and citrate being known inhibitors and ADP being a known activator.

Here are the steps to answer your question:

1. ATP: ATP is an inhibitor of PFK1. When ATP levels are high, it binds to PFK1 and decreases its activity. This makes sense because high ATP levels signal that the cell has enough energy, so it doesn't need to break down more glucose through glycolysis.

2. ADP: ADP is an activator of PFK1. When ADP levels are high, it binds to PFK1 and increases its activity. This is because high ADP levels signal that the cell needs more energy, so it needs to break down more glucose through glycolysis.

3. Citrate: Citrate is an inhibitor of PFK1. When citrate levels are high, it binds to PFK1 and decreases its activity. This is because high citrate levels signal that the cell has enough building blocks for the citric acid cycle, so it doesn't need to break down more glucose through glycolysis.

4. Acetyl CoA: Acetyl CoA does not directly regulate PFK1. However, it is a product of glycolysis and can be used in the citric acid cycle to produce ATP.

So, the answer to your question is "ADP".

The activity of phosphofructokinase 1 is increased by the binding ofGroup of answer choicesATPADPCitrateAcetyl CoATwo or more of the above

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The activity of phosphofructokinase 1 is increased by the binding of

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