The main determinant of the rate of mitochondrial fatty acid oxidation is the activity of the enzyme Carnitine Palmitoyltransferase I (CPT I).

Here's a step-by-step explanation:

1. Fatty acids enter the cell and are activated to form fatty acyl-CoA in the cytoplasm.

2. The fatty acyl-CoA cannot directly cross the mitochondrial membrane. It must be transported into the mitochondria via the carnitine shuttle.

3. The enzyme Carnitine Palmitoyltransferase I (CPT I) located on the outer mitochondrial membrane, converts the fatty acyl-CoA to acylcarnitine.

4. The acylcarnitine is then transported across the inner mitochondrial membrane.

5. Once inside the mitochondria, the acyl group is transferred back to CoA, and the carnitine is returned to the cytosol.

6. The fatty acyl-CoA is then ready for oxidation in the mitochondrial matrix.

The rate-limiting step in this process is the conversion of fatty acyl-CoA to acylcarnitine by CPT I. Therefore, the activity of this enzyme is the main determinant of the rate of mitochondrial fatty acid oxidation.

Question

The main determinant of the rate of mitochondrial fatty acid oxidation is the activity of the enzyme Carnitine Palmitoyltransferase I (CPT I).

Here's a step-by-step explanation:

1. Fatty acids enter the cell and are activated to form fatty acyl-CoA in the cytoplasm.

2. The fatty acyl-CoA cannot directly cross the mitochondrial membrane. It must be transported into the mitochondria via the carnitine shuttle.

3. The enzyme Carnitine Palmitoyltransferase I (CPT I) located on the outer mitochondrial membrane, converts the fatty acyl-CoA to acylcarnitine.

4. The acylcarnitine is then transported across the inner mitochondrial membrane.

5. Once inside the mitochondria, the acyl group is transferred back to CoA, and the carnitine is returned to the cytosol.

6. The fatty acyl-CoA is then ready for oxidation in the mitochondrial matrix.

The rate-limiting step in this process is the conversion of fatty acyl-CoA to acylcarnitine by CPT I. Therefore, the activity of this enzyme is the main determinant of the rate of mitochondrial fatty acid oxidation.

Knowee AI · Accepted Answer

The main determinant of the rate of mitochondrial fatty acid oxidation is the activity of the enzyme Carnitine Palmitoyltransferase I (CPT I).

Here's a step-by-step explanation:

1. Fatty acids enter the cell and are activated to form fatty acyl-CoA in the cytoplasm.

2. The fatty acyl-CoA cannot directly cross the mitochondrial membrane. It must be transported into the mitochondria via the carnitine shuttle.

3. The enzyme Carnitine Palmitoyltransferase I (CPT I) located on the outer mitochondrial membrane, converts the fatty acyl-CoA to acylcarnitine.

4. The acylcarnitine is then transported across the inner mitochondrial membrane.

5. Once inside the mitochondria, the acyl group is transferred back to CoA, and the carnitine is returned to the cytosol.

6. The fatty acyl-CoA is then ready for oxidation in the mitochondrial matrix.

The rate-limiting step in this process is the conversion of fatty acyl-CoA to acylcarnitine by CPT I. Therefore, the activity of this enzyme is the main determinant of the rate of mitochondrial fatty acid oxidation.

The activity of this enzyme is the main determinant of the rate of mitochondrial fatty acid oxidation:Group of answer choicesCPTPDHHAD

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