People with a disorder that disrupts tryptophan metabolism may have a deficiency of .

People with a disorder that disrupts tryptophan metabolism may have a deficiency of serotonin.

Here's why:

1. Tryptophan is an essential amino acid, which means our bodies can't produce it and we must get it from our diet.

2. Once in the body, tryptophan is converted into 5-hydroxytryptophan (5-HTP) with the help of an enzyme.

3. 5-HTP is then converted into serotonin, a neurotransmitter that helps regulate mood, appetite, and sleep.

4. Therefore, if there's a disruption in tryptophan metabolism, the body may not be able to produce enough serotonin, leading to a deficiency.

5. A deficiency in serotonin can lead to symptoms such as depression, anxiety, sleep disorders, and other mental health conditions.