Anosmia, the loss of the sense of smell, can be caused by the deletion of specific genes that are essential for olfactory function. In mice, one of the key genes associated with olfactory function is the **Olfr gene** (olfactory receptor gene). Additionally, genes involved in the olfactory signaling pathways, such as those encoding specific olfactory receptors (like the **OR** genes) or signaling proteins (e.g., **Gαolf**), may also lead to anosmia when they are knocked out.

Research has shown that deleting the **Trp53 (p53)** gene has been linked to altered olfactory function, and other genes regulating the development and function of olfactory sensory neurons may lead to anosmia when disrupted.

To conclude, removing genes vital for the development or function of olfactory receptors, such as the **Olfr** genes or those involved in olfactory neuron signaling pathways, would lead to anosmia in a mouse model.

Question

Anosmia, the loss of the sense of smell, can be caused by the deletion of specific genes that are essential for olfactory function. In mice, one of the key genes associated with olfactory function is the **Olfr gene** (olfactory receptor gene). Additionally, genes involved in the olfactory signaling pathways, such as those encoding specific olfactory receptors (like the **OR** genes) or signaling proteins (e.g., **Gαolf**), may also lead to anosmia when they are knocked out.

Research has shown that deleting the **Trp53 (p53)** gene has been linked to altered olfactory function, and other genes regulating the development and function of olfactory sensory neurons may lead to anosmia when disrupted.

To conclude, removing genes vital for the development or function of olfactory receptors, such as the **Olfr** genes or those involved in olfactory neuron signaling pathways, would lead to anosmia in a mouse model.

Knowee AI · Accepted Answer

Anosmia, the loss of the sense of smell, can be caused by the deletion of specific genes that are essential for olfactory function. In mice, one of the key genes associated with olfactory function is the **Olfr gene** (olfactory receptor gene). Additionally, genes involved in the olfactory signaling pathways, such as those encoding specific olfactory receptors (like the **OR** genes) or signaling proteins (e.g., **Gαolf**), may also lead to anosmia when they are knocked out.

Research has shown that deleting the **Trp53 (p53)** gene has been linked to altered olfactory function, and other genes regulating the development and function of olfactory sensory neurons may lead to anosmia when disrupted.

To conclude, removing genes vital for the development or function of olfactory receptors, such as the **Olfr** genes or those involved in olfactory neuron signaling pathways, would lead to anosmia in a mouse model.

A mouse model with anosmia has been generated using gene knockout techniques. Removing which gene would lead to anosmia?

Question

A mouse model with anosmia has been generated using gene knockout techniques.

Solution

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