Which enzyme is responsible for converting IMP (inosine monophosphate) to AMP (adenosine monophosphate) in the purine nucleotide biosynthesis pathway?
Question
Which enzyme is responsible for converting IMP (inosine monophosphate) to AMP (adenosine monophosphate) in the purine nucleotide biosynthesis pathway?
Solution
The enzyme responsible for converting IMP (inosine monophosphate) to AMP (adenosine monophosphate) in the purine nucleotide biosynthesis pathway is called inosine monophosphate dehydrogenase. This reaction is part of a crucial step in the de novo purine biosynthesis pathway, where the conversion of IMP to AMP involves the addition of an amino group from aspartate and the release of fumarate, with the assistance of the enzyme adenylosuccinate synthetase. This process highlights the intricate network of enzymatic reactions involved in purine metabolism.
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