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A father has DMD. He has two daughters, one is normal while the other daughter had DMD. Identify the genotype and phenotype of the mother.  Marks = 3

Question

A father has DMD. He has two daughters, one is normal while the other daughter had DMD. Identify the genotype and phenotype of the mother.

Marks = 3

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Solution

Duchenne Muscular Dystrophy (DMD) is a recessive X-linked genetic disorder. This means a male with the disorder (who has only one X chromosome) will pass the affected X chromosome to all of his daughters but none of his sons.

  1. Genotype of the Mother: Since one of the daughters has DMD, the mother must be a carrier of the DMD gene. This means she has one normal X chromosome (X) and one affected X chromosome (X'). So, the genotype of the mother is X'X.

  2. Phenotype of the Mother: Even though the mother carries the DMD gene, she does not show symptoms of the disease because it is a recessive disorder. This means the normal X chromosome compensates for the affected one. Therefore, the phenotype of the mother is normal.

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