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Identify the genotypes of...1) a woman with normal blood clotting whose fatherhad hemophilia2) a normal man whose father had hemophilia.

Question

Identify the genotypes of...

  1. a woman with normal blood clotting whose father had hemophilia
  2. a normal man whose father had hemophilia.
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Solution

Hemophilia is a sex-linked recessive disorder, which means it's carried on the X chromosome.

  1. A woman with normal blood clotting whose father had hemophilia:

The father, having hemophilia, would have the genotype X^hY (where X^h represents the X chromosome with the hemophilia allele and Y represents the Y chromosome). The woman, having normal blood clotting, must have at least one normal X chromosome. Since she got her Y chromosome from her father, she must have gotten her normal X chromosome from her mother. Therefore, her genotype would be X^HX^h (where X^H represents the X chromosome with the normal allele). This means she is a carrier of the hemophilia gene.

  1. A normal man whose father had hemophilia:

The father, having hemophilia, would have the genotype X^hY. Men only have one X chromosome, which they get from their mothers. Since the man is normal, he must have gotten a normal X chromosome from his mother. Therefore, his genotype would be X^HY (where X^H represents the X chromosome with the normal allele). This means he does not carry the hemophilia gene.

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