The following are enzymes required in DNA replication except A. DNA helicase B. Topoisomerase C. DNA primase D. DNA synthase

To identify which of the listed enzymes is not required in DNA replication, let's analyze each option accurately.

1. DNA helicase: This enzyme unwinds the DNA double helix, allowing the replication process to occur. It is essential for separating the two strands of DNA.

2. Topoisomerase: This enzyme helps relieve the tension created ahead of the replication fork as the DNA unwinds. It is also crucial for DNA replication.

3. DNA primase: This enzyme synthesizes short RNA primers to initiate the synthesis of a new DNA strand. It is vital for starting DNA replication.

4. DNA synthase: This term appears to be incorrect. The correct term is likely "DNA polymerase," which synthesizes new DNA strands. If "DNA synthase" is referring to an enzyme that does this, it could be conflated terminology, but it's not typically one of the core enzymes identified for DNA replication.

Conclusion

The option that does not accurately correspond to an established enzyme involved in DNA replication is D. DNA synthase.

Thus, the correct answer is:

Final Answer

D. DNA synthase