What is the enzyme responsible for resolution of a DNA heteroduplex during homologous recombination?RecORuvCRecARuvAB

The enzyme responsible for the resolution of a DNA heteroduplex during homologous recombination is known as RuvC. During the process of homologous recombination, the formation of a heteroduplex occurs when two homologous DNA strands exchange genetic information. Following this exchange, the structures that form, known as holliday junctions, need to be resolved into separate DNA strands.

RuvC is an endonuclease that specifically recognizes these holliday junctions and cleaves them, allowing the recombination process to be completed. It works in conjunction with other proteins, including RuvA and RuvB, which facilitate the branch migration of the junction before RuvC resolves it. In summary, RuvC is crucial for ensuring the integrity and proper segregation of genetic material during cell division through its role in resolving DNA heteroduplexes.