When cells are infected with viruses such as SARS-CoV-2 they can release interferons. Describe the role of interferons.
Question
When cells are infected with viruses such as SARS-CoV-2 they can release interferons. Describe the role of interferons.
Solution
Interferons are a group of signaling proteins produced and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses. Here's a step-by-step description of their role:
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Virus Detection: When a cell gets infected by a virus such as SARS-CoV-2, it recognizes the foreign entity through various receptors. These receptors detect the viral RNA and trigger an immune response.
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Interferon Production: This immune response leads to the production of interferons. These are proteins that are part of the body's innate immune system. They interfere with viral replication within the host cell, hence the name 'interferon'.
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Interferon Release: The infected cell releases these interferons, which then bind to interferon receptors on the surface of neighboring cells.
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Signal Transduction: Once the interferons have bound to these receptors, they activate a specific set of genes within these cells. This is done through a complex signal transduction pathway involving several proteins.
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Antiviral State: The activation of these genes sets up an antiviral state within these cells. This means that the cells increase their defenses, making
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