Which molecule serves as the primer for fatty acid synthesis?A) Acetyl-CoAB) Malonyl-CoAC) PalmitateD) Acyl carrier protein (ACP)
Question
Which molecule serves as the primer for fatty acid synthesis?
A) Acetyl-CoA
B) Malonyl-CoA
C) Palmitate
D) Acyl carrier protein (ACP)
Solution
The molecule that serves as the primer for fatty acid synthesis is Acetyl-CoA (Option A).
Here's a step-by-step explanation:
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Fatty acid synthesis begins with the carboxylation of Acetyl-CoA to form Malonyl-CoA. This reaction is catalyzed by the enzyme Acetyl-CoA carboxylase.
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The Malonyl-CoA is then attached to the Acyl carrier protein (ACP), forming Malonyl-ACP.
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However, the initial primer for the synthesis is Acetyl-CoA, not Malonyl-CoA. This is because the first two carbons of the fatty acid chain come from Acetyl-CoA.
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The Acetyl group of Acetyl-CoA is transferred to the ACP, forming Acetyl-ACP.
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The Acetyl-ACP then reacts with Malonyl-ACP in a series of reactions to elongate the fatty acid chain.
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This process continues, with each cycle adding two carbons to the fatty acid chain, until the final product, Palmitate, is formed.
So, while Malonyl-CoA, ACP, and Palmitate are all involved in fatty acid synthesis, the primer for the process is Acetyl-CoA.
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