GRANULOMA IS A MANIFESTATION OF ____ HYPERSENSITIVITY REACTIONA antibody-mediatedB cell-mediatedIN immune complexD anaphylactic

Break Down the Problem

1. Identify the type of hypersensitivity reaction associated with granuloma formation.
2. Review the options provided to determine which is correct.

Relevant Concepts

• Hypersensitivity Reactions: There are four types:
  • Type I: Anaphylactic (IgE mediated)
  • Type II: Antibody-mediated (IgG or IgM)
  • Type III: Immune complex-mediated
  • Type IV: Cell-mediated (T-cell mediated)

Analysis and Detail

• Granulomas are a collection of macrophages that have transformed into epithelioid cells and are often a response to persistent pathogens or antigens. This type of immune response is primarily due to cell-mediated immunity.
• Given the options:
  • A: Antibody-mediated - relates to type II hypersensitivity.
  • B: Cell-mediated - corresponds to type IV hypersensitivity, which is indeed associated with granulomas.
  • C: Immune complex - refers to type III hypersensitivity.
  • D: Anaphylactic - refers to type I hypersensitivity.

Verify and Summarize

From the analysis, it is clear that granuloma formation arises from a cell-mediated immune response, making option B the correct answer.

Final Answer

Granuloma is a manifestation of B. cell-mediated hypersensitivity reaction.