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Which ONE of the following ketone bodies cannot be used to make ATP?Group of answer choicesAcetoneAcetyl CoABeta hydroxybutyrateAcetoacetate

Question

Which ONE of the following ketone bodies cannot be used to make ATP?

  • Acetone
  • Acetyl CoA
  • Beta hydroxybutyrate
  • Acetoacetate
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Solution

To determine which one of the following ketone bodies cannot be used to make ATP, we need to understand their metabolic pathways. Ketone bodies are produced in the liver during periods of prolonged fasting or low carbohydrate intake.

  1. Acetone: Acetone is a ketone body that is produced as a byproduct of the breakdown of acetoacetate. It is not directly used to make ATP but is instead excreted through the breath and urine.

  2. Acetyl CoA: Acetyl CoA is not a ketone body but a molecule that is produced during the breakdown of carbohydrates, fats, and proteins. Acetyl CoA enters the citric acid cycle (also known as the Krebs cycle) and is used to generate ATP.

  3. Beta hydroxybutyrate: Beta hydroxybutyrate is a ketone body that is produced in the liver from acetoacetate. It can be converted back into acetyl CoA and used to generate ATP.

  4. Acetoacetate: Acetoacetate is a ketone body that is produced in the liver from acetyl CoA. It can be converted into beta hydroxybutyrate or spontaneously decarboxylated to form acetone. Acetoacetate can also be converted back into acetyl CoA and used to generate ATP.

Based on the information above, the ketone body that cannot be directly used to make ATP is acetone.

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