Which of the following is/are involved in the initiation of DNA replication? (A) RhoA (B) oriC (C) Sigma factor (D) DnaA

The initiation of DNA replication in bacteria involves the recognition of the origin of replication (oriC) by the initiator protein DnaA. DnaA binds to the oriC sequence, causing the DNA to unwind and open up, allowing other proteins to bind and begin the process of replication. Therefore, the correct answer is (B) oriC and (D) DnaA.

RhoA (A) is a small GTPase protein and is involved in the regulation of the actin cytoskeleton, not DNA replication. The sigma factor (C) is a bacterial transcription initiation factor that enables specific binding of RNA polymerase to gene promoters, not involved in DNA replication.