An electrophoretic separation of lactate dehydrogenase isoenzyme that demonstrates elevation in LD-1 greater than LD-2 could be indicative of:
Question
An electrophoretic separation of lactate dehydrogenase isoenzyme that demonstrates elevation in LD-1 greater than LD-2 could be indicative of:
Solution
An elevation in LD-1 greater than LD-2 in an electrophoretic separation of lactate dehydrogenase isoenzyme could be indicative of a myocardial infarction, also known as a heart attack.
Here's a step-by-step explanation:
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Lactate dehydrogenase (LDH) is an enzyme found in almost all body tissues, but only released into the bloodstream when there's tissue damage.
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LDH is made up of five isoenzymes, which can be separated by electrophoresis. These isoenzymes are LD-1, LD-2, LD-3, LD-4, and LD-5.
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Under normal conditions, the LD-1 level is lower than the LD-2 level in the blood.
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However, when a heart attack occurs, heart cells are damaged and release their LDH. The LDH from heart cells is primarily LD-1.
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Therefore, after a heart attack, the LD-1 level in the blood can become higher than the LD-2 level. This is known as a "flipped LDH pattern" and is a strong indicator of a recent heart attack.
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So, an electrophoretic separation of lactate dehydrogenase isoenzyme that shows an elevation in LD-1 greater than LD-2 could be indicative of a myocardial infarction.
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