The cleavage between Asn-Pro is carried out by (a) Cyanogen Bromide (b) Hydroxylamine (c) Trypsin (d) Factor Xa
Question
The cleavage between Asn-Pro is carried out by
(a) Cyanogen Bromide
(b) Hydroxylamine
(c) Trypsin
(d) Factor Xa
Solution
The cleavage between Asn-Pro is carried out by (b) Hydroxylamine.
Here's a step-by-step explanation:
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The question is asking which agent is responsible for cleaving (breaking) the bond between the amino acids Asparagine (Asn) and Proline (Pro).
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Cyanogen Bromide (a) is a reagent that specifically cleaves at the carboxyl side of Methionine residues.
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Trypsin (c) is an enzyme that cleaves proteins at the carboxyl side of the amino acids lysine and arginine, except when either is followed by proline.
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Factor Xa (d) is an enzyme that cleaves at the carboxyl side of the arginine residue in the sequence Ile-Glu-Gly-Arg, it doesn't cleave between Asn-Pro.
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Hydroxylamine (b) is a reagent that specifically cleaves Asn-Gly bonds, but it can also cleave Asn-Pro bonds under certain conditions. Therefore, the correct answer is (b) Hydroxylamine.
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