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A mutation converts an AGA codon to a TAA codon . This mutation is a:Termination mutationNoncoding mutationNonsense mutationMissense mutation

Question

A mutation converts an AGA codon to a TAA codon. This mutation is a:

  • Termination mutation
  • Noncoding mutation
  • Nonsense mutation
  • Missense mutation
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Solution

To determine the type of mutation that converts an AGA codon to a TAA codon, let's analyze the codons:

  1. Understanding the Codons:

    • AGA codon corresponds to the amino acid Arginine (Arg).
    • TAA codon is a stop codon (specifically UAA in RNA), which signals termination of protein synthesis.
  2. Types of Mutations:

    • Termination Mutation: Typically refers to a mutation that introduces a stop codon.
    • Noncoding Mutation: Refers to a mutation that does not affect the coding sequence of a gene.
    • Nonsense Mutation: This is a specific type of mutation where a codon that codes for an amino acid is changed into a stop codon, leading to premature termination of the protein.
    • Missense Mutation: A mutation resulting in a codon that codes for a different amino acid.
  3. Identification:

    • Since the AGA (Arg) is converted to TAA (stop), the function of the gene product is likely to be truncated, resulting in a shorter, likely nonfunctional protein.

Conclusion

This mutation is classified as a Nonsense mutation because it changes a codon for an amino acid into a stop codon, resulting in early termination of protein synthesis.

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