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If a wild-type DNA sequence reads AAA ACG CCG AGG, what type of mutation would change it to AAA ACC CCG AGG?ANSWERFrameshiftDeletionMissenseInsertion

Question

If a wild-type DNA sequence reads AAA ACG CCG AGG, what type of mutation would change it to AAA ACC CCG AGG?

Options:

  • Frameshift
  • Deletion
  • Missense
  • Insertion
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Solution

To determine the type of mutation that changes the wild-type DNA sequence from AAA ACG CCG AGG to AAA ACC CCG AGG, follow these steps:

  1. Identify the original sequence: AAA ACG CCG AGG

  2. Identify the mutated sequence: AAA ACC CCG AGG

  3. Compare the sequences:

    • Original: AAA ACG CCG AGG
    • Mutated: AAA ACC CCG AGG
  4. Locate the change: The second triplet changes from ACG to ACC.

  5. Determine the type of mutation:

    • Frameshift: This involves insertion or deletion of nucleotides that are not in multiples of three, causing a shift in the reading frame. This is not the case here.
    • Deletion: This involves the removal of one or more nucleotides. This is not the case here.
    • Missense: This involves a single nucleotide change that results in a codon that codes for a different amino acid. This is the case here.
    • Insertion: This involves the addition of one or more nucleotides. This is not the case here.

The correct answer is Missense.

This problem has been solved

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