If a wild-type DNA sequence reads AAA ACG CCG AGG, what type of mutation would change it to AAA ACC CCG AGG?ANSWERFrameshiftDeletionMissenseInsertion
Question
If a wild-type DNA sequence reads AAA ACG CCG AGG
, what type of mutation would change it to AAA ACC CCG AGG
?
Options:
- Frameshift
- Deletion
- Missense
- Insertion
Solution
To determine the type of mutation that changes the wild-type DNA sequence from AAA ACG CCG AGG to AAA ACC CCG AGG, follow these steps:
-
Identify the original sequence: AAA ACG CCG AGG
-
Identify the mutated sequence: AAA ACC CCG AGG
-
Compare the sequences:
- Original: AAA ACG CCG AGG
- Mutated: AAA ACC CCG AGG
-
Locate the change: The second triplet changes from ACG to ACC.
-
Determine the type of mutation:
- Frameshift: This involves insertion or deletion of nucleotides that are not in multiples of three, causing a shift in the reading frame. This is not the case here.
- Deletion: This involves the removal of one or more nucleotides. This is not the case here.
- Missense: This involves a single nucleotide change that results in a codon that codes for a different amino acid. This is the case here.
- Insertion: This involves the addition of one or more nucleotides. This is not the case here.
The correct answer is Missense.
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