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Rearrangement of the T cell receptor _______ gene results in the deletion of the T cell receptor _____ gene.1 pointα; γα; δβ; γβ; δδ; α

Question

Rearrangement of the T cell receptor _______ gene results in the deletion of the T cell receptor _____ gene.

1 point
α;
γα;
δβ;
γβ;
δδ;
α

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Solution

The correct answer is δ; α.

Explanation:

In T cell development, the rearrangement of the T cell receptor δ (delta) gene occurs within the context of the T cell receptor (TCR) locus, leading to the deletion of the T cell receptor α (alpha) gene. This process is essential for the development of T cells and is part of the mechanism that ensures proper T cell receptor functionality. The delta gene is located within the alpha locus, and its rearrangement consequently results in the loss of the alpha gene segment from the genome, which is a crucial event in T cell maturation.

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